Are you planning on charging admission for this show?
Just kidding I did a similiar drill job, but it was only a 20 gal sump , that I couldnt get out from under my stand. Like mentioned before keep the area lubed, I used RO/DI water. Otherwise I drained the water level about 2 in below where I drilled and used a piece of styrofoam on the inside portion of the glass to catch any shavings. I was very cautious, but now its no big deal to drill glass.
Are you using the drill bit or dremmel approach?