So the GAC seems fine (especially since you also did some water changes). Maybe add 25% more when you change it out, JIC? Maybe change it weekly? If you have decent flow, the the GAC should pull out the toxins pretty fast. Whatever the GAC misses, the protein skimmer will pull out. But what you described is pretty standard, and I have not read anything about mushrooms pumping out so much toxin that your regimen couldn't handle it.
Cubes of copepods or other zooplankters? Maybe feed 2x a week? Could have been surviving for a long time, but not thriving, and now they are withering.
Good luck!
J