I'd go with two, 100-150w heaters and probably leaning toward the lower wattage unit (100-125w) provided your aquarium isnt in an abnormally cold area of the home or you like keeping the home cooler than about 65°. The reason being, if one heater malfunctions and stays in the on position, it will take longer to heat the aquarium to an unacceptable level giving you more time to identify and correct the problem.