I also went through a bad case of dinos. Strangely enough Microbe Lift special blend seemed to knock them out. I tried lights out for five days and they just came back 3 weeks later (BTW lights out for dinos means tank wrapped in black trash bags) . I used the microbe lift and it wiped them out. Also if you dose solid carbons (i.e. vodka) it will get worse. I think someone said this, but water changes will make it worse also. I would try the microbe lift, it's only a couple bucks and it definitely can't hurt. I will warn you that it stinks BAD, I would do it when no one will be home for a while. Smells like dirty skimmer x10